A History of Poisons

By Jean Henry Mead


The discovery of poisons occurred when prehistoric tribes foraged for food; an often deadly experience, or what would later be known as Russian roulette. Primitive poison experts were people to be reckoned with, and they either served as tribal sorcerers or were burned at the stake, depending on whom they practiced.

Our first written accounts of poisonings are from the Roman era over 2,000 years ago, although the Chinese, Egyptians, Sumerians and Indians had practiced the art of poisoning for centuries. Cleopatra allegedly used her slaves and prisoners as guinea pigs while searching for the perfect suicidal poison. She tried belladonna and found that it killed quickly but was too painful for her own personal demise. She also tried an early form of strychnine but it caused facial distortions at death, so she chose instead the bite of an asp, a small African cobra, which produced a quick and painless death.

Those in some cultures were so afraid of being poisoned that they consumed gradual amounts of various poisons on a regular basis to build up their immunity to them. Dorothy L. Sayers, in her book, Strong Poisons, had her villain doing just that, as did Alexander Dumas in The Count of Monte Cristo.

Food tasters were employed by most royals. If they survived, after sampling each dish, the king would consent to eat his meal. The job must have paid well, or a steady stream of prisoners were employed against their will.

The use of poison-tipped arrows during the Renaissance period paved the way for modern pharmacology. Drugs such as astropine, digitalis and ouabain evolved from plant concoctions used for killing both people and animals. And we now know that thousands of people are killed each year with current pharmaceutical prescriptions.

The Roman Borgia family of the fifteen century was a dynasty of poisoners, according to Serita Deborah Stevens in her book, Deadly Doses. If Casare Borgia were offended by something someone said, the unsuspecting person was invited to attend a party and would leave seriously ill or in the back of a mortician’s wagon. Borgia's poison of choice was arsenic, the favorite of assassins of that era.

Bernard Serturner isolated morphine from opium in 1805, but the formal study of poisons began with Claude Bernard, a physiologist, who researched the effects of curare, a South American poison the Indians used to tip their arrows. Chemical analysis could detect most mineral compounds by 1830, although not organic poisons. By 1851, a Belgian chemist discovered the technique of extracting alkaloid poisons while investigating a homicide caused by nicotine, a very deadly poison. Jean Servais Stas was the first to isolate nicotine from postmortem tissue.

The use of poison as a means of murder declined when modern methods of detection were perfected and physicians began saving many of its victims.